基于钯催化烯丙基取代的不对称串联反应是直接构建具有生理活性的手性杂环化合物的有效途径之一。然而，现有文献主要是针对合成手性单杂环化合物，且环上取代基往往较少，不对称催化效果一般也较差。在申请者对不对称烯丙基取代反应和不对称串联反应两方面的多年研究基础上，本申请设计了几类基于钯催化烯丙基取代反应的不对称串联反应，以期方便高效地构建多手性中心的杂多环化合物。申请者已针对上述内容做了大量的前期研究，均取得了可喜的初步结果。例如对于多手性中心的骈杂环化合物的不对称催化合成，已取得高达99% ee及20/1 dr的选择性。这些结果显示，本申请所设计的几类新型不对称串联反应具有很好的可行性。本申请拟在此基础上，进一步提高这些反应的催化效果、拓展底物的适用范围，并将这些反应应用于生物活性分子和药物及其关键中间体的高效合成。该课题的完成将为一系列多手性中心的杂多环类化合物的高效合成提供新思路和新方法

Pd-Catalyzed asymmetric cascade reactions based on allylic substitutions are efficient procedures for the construction of bioactive chiral heterocyclic compounds. However, in addition to somewhat poor catalytic results, current strategies mainly allow for the synthesis of single heterocycles bearing a few chiral centers. Based on long-term research in the field of asymmetric allylic substitutions and cascade reactions, several Pd-catalyzed asymmetric cascade reactions based on allylic substitutions have been designed for the convenient construction of complex heterocyclic compounds bearing multiple stereocenters. We have carried out preliminary studies concerning the above mentioned asymmetric cascade reaction and obtained promising results. For example, fused heterocyclic compound with multiple chiral centers could be synthesized with up to 99% ee and 20/1 dr. These results show that the above designed cascade reactions are of good feasibility. Further work concerns improving the asymmetric catalytic behavior, exploring substrate scope and applying these cascade reactions to the efficient synthesis of biologically active molecules, drugs and their key intermediates. The research will provide an efficient pathway towards the synthesis of complex heterocyclic compounds with multiple chiral centers.