The effect of maternal aging on the quality of eggs

产妇年龄的增加与生育能力的逐渐丧失、流产的增加以及生育有先天缺陷的孩子的风险增加有关。这些不利的生殖结果部分是由于卵子质量随着年龄的增长而下降。我们的目标是识别和表征与年龄相关的卵子质量下降有关的基因。这项研究的长期目标是开发新的策略，以改善选择推迟怀孕的妇女的生育结果。

Advancing maternal age is associated with the progressive loss of fertility, increased miscarriage and a greater risk of bearing children with birth defects. These adverse reproductive outcomes result, in part, from the loss of egg quality with age. We aim to identify and characterise genes involved in the age-related decline in egg quality. The long-term goal of this research is to develop novel strategies to improve fertility outcomes for women who chose to delay pregnancy until later in life.