The effects of intestinal inflammation on the currents and channels of identified enteric neurons

肠炎，如胃肠炎、克罗恩病、回肠炎或结肠炎，会影响胃肠道的运动和分泌。公认的症状是消化不良、痉挛疼痛和腹泻。这些症状通常在炎症消退后仍会继续。炎症后可能发展的主要疾病实体是肠易激综合征(IBS)。肠易激综合征与持续性的肠动力障碍有关。这些症状是由肠道神经元特性的变化引发的，其中许多变得过度兴奋。肠道神经元是肠壁内神经系统的一部分。然而，炎症后改变属性的神经元尚未被鉴定，改变的机制也不清楚。这项工作旨在确定神经元兴奋性变化导致过度兴奋性的分子基础。识别其性质发生变化的分子将使这些分子成为化合物设计的靶点，以治疗炎症后的肠道生理异常。

Intestinal inflammation, in gastroenteritis, Crohn's disease, ileitis or colitis, has effects on the motility (movement) of the gastrointestinal and on secretion within it. The symptoms that are recognised are poor digestion, crampy pains and diarrhoea. The symptoms often continue after the inflammation has subsided. The major disease entity that can develop after inflammation is the irritable bowel syndrome (IBS). IBS is associated with persistent disorders of bowel motility. The symptoms are triggered by changes in the properties of enteric neurons, many of which become hyperexcitable. Enteric neurons are part of the nervous system within the gut wall. However, the neurons that have changed properties after inflammation have not been identified, and the mechanisms of change are not known. This work is designed to determine the molecular basis of the changes in neuron excitability that lead to hyperexcitability. Identification of the molecules whose properties are changed will permit those molecules to be targeted in the design of compounds to treat the abnormalities of intestinal physiology that follow inflammation.