The effects of maternal infection on glutamate-related behavioural, electrophysiological and neuropathological measures relevant to schizophrenia

关于精神分裂症有两个众所周知的事实：母亲感染增加了成年后被诊断为精神分裂症的风险；影响特定大脑化学物质的某些药物，如PCP，会在健康个体中诱发与精神分裂症相似的症状和大脑变化。在这里，我们将这两个事实结合起来，试图在啮齿动物中建立一种模仿精神分裂症中所见的大脑变化的母体感染模型，从而为治疗开辟新的选择。

There are two well known facts about schizophrenia: maternal infection increases the risk of a schizophrenia diagnosis in adulthood and certain drugs, such as PCP, that affect particular brain chemicals induce symptoms and brain changes in healthy individuals that are similar to schizophrenia. Here we bring these two facts together by attempting to develop a maternal infection model in rodents that mimics the brain changes seen in schizophrenia, thus opening up new options for treatment.