The Efficacy of N-acetylcysteine as an adjunctive treatment in unipolar depression

这是抑郁症患者大脑的抗氧化防御系统，尤其是谷胱甘肽发生改变的证据。N-乙酰半胱氨酸(NAC)是一种谷胱甘肽前体，在双相情感障碍中具有增强抗氧化防御和抗抑郁特性。这项研究的目的是观察NAC治疗是否能防止复发并改善抑郁症的症状，包括功能和生活质量。参与者将被随机给予NAC或安慰剂，除了标准的治疗。

This is evidence that the brain's antioxidant defences, particularly glutathione, are altered in depression. N-acetylcysteine (NAC), a glutathione precursor, increases antioxidant defences and has antidepressant properties in bipolar disorder. The aim of this study is to see if treatment with NAC will precent relapse and improve the symptoms of depression including functioning and quality of life. Participants will be randomly given either NAC or placebo, in addition to standard thereapy.