The identification of new epilepsy genes by whole genome sequencing

癫痫是一种常见的大脑疾病，全世界约有5000万人受到影响。最常见的癫痫类型是局灶性癫痫。我们小组最近证明了基因突变作为局灶性癫痫的原因的重要性。利用现代基因组技术，我们将发现局灶性癫痫的新基因。我们将建立这些基因的动物模型，以更好地了解癫痫的病理生物学，从而为患者开发新的治疗方法。

Epilepsy is a common brain disorder affecting approximately 50 million people worldwide. The most common type of epilepsy is known as focal epilepsy. Our group has recently shown the importance of genetic mutations as causes of focal epilepsy. Using modern genomic technologies we will identify new genes in focal epilepsy. We will make animal models of these genes to better understand the pathobiology of epilepsy so that new treatments can be developed for patients.