The impact of influenza A virus PB1-F2 protein on host immunity and the potential for therapeutic targeting

1918年流感病毒大流行导致全球5000万人死亡，并有可能出现新的大流行，如预测的H5N1禽流感。造成这种毁灭性死亡的确切原因尚未完全确定。新发现的甲型流感病毒(IAV)PB1-F2蛋白存在于几乎所有高致病性IAV中，并促进病毒的毒力。这项研究将进一步研究PB1-F2对宿主的影响方式，揭示减轻疾病负担的潜在治疗靶点。

The 1918 influenza virus pandemic resulted in 50 million deaths globally and there is potential for new pandemics, such as the predicted H5N1 Bird Flu . Exact causes of such devastating lethality are not fully identified. Newly discovered influenza A virus (IAV) PB1-F2 protein is present in nearly all highly pathogenic IAVs and promotes virus virulence. This study will further examine the way in which PB1-F2 impacts the host, revealing potential therapeutic targets to lessen disease burden.