The interplay between viperin, peroxisomes and the cellular innate antiviral response

病毒感染启动细胞抗病毒反应，试图限制病毒复制，但这种反应是如何调节的还不清楚。在这个提议中，我们将研究一种细胞蛋白（蝰蛇蛋白），它可以通过与过氧化物酶体相互作用来调节这一过程，以放大抗病毒反应。这项工作将为先天免疫反应的治疗操纵提供可能的靶点，该靶点将适用于广泛的病毒感染。

Infection with a virus initiates a cellular antiviral response that attempts to limit viral replication, however how this response is regulated is not well understood. In this proposal we will investigate a cellular protein (viperin) that can regulate this process by interaction with peroxisomes to amplify the antiviral response. This work will provide possible targets for therapeutic manipulation of the innate immune response that will be applicable to a wide range of viral infections.