The mechanism of synthetic lethality between BRCA1/2 and Fanconi anaemia E3 ligase activity

癌症影响着三分之一的人，一种常见的化疗是导致DNA损伤的化疗。虽然化疗可以杀死肿瘤细胞并缩小肿瘤大小，但由于癌症对化疗产生耐药性，许多患者因治疗失败而复发并死亡。我们在细胞如何修复化疗引起的DNA损伤方面取得了重大进展。我们现在能够寻找能够使传统和尖端癌症治疗更有效的药物。

Cancer affects one in three people in their lives and a common type of chemotherapy is one that causes DNA damage. While chemotherapy can kill cells in tumors and reduce tumor size, many patients relapse and die because of treatment failure as the cancer can become resistant to chemotherapy. We have made major advances about how cells repair the DNA damage caused by chemotherapy. We are now able to search for drugs that could make traditional and cutting edge cancer treatments more effective.