The NF-kB transcription factors c-Rel and RelA control multiple steps in natural CD4 regulatory T cell development

免疫功能的一个不幸后果是，偶尔会产生流氓免疫细胞，攻击宿主，导致关节炎等所谓的自身免疫性疾病的发展。正常情况下，一种名为调节性T细胞的白细胞会抑制这些自我反应性免疫细胞。我们已经确定了控制调节性T细胞产生的因素。了解这些因素是如何发挥作用的，应该可以开发出抗击自身免疫性疾病的新策略。？

An unfortunate consequence of immune function is that occasionally rogue immune cells are produced that attack the host and lead to the development of so-called autoimmune diseases such as arthritis. Normally a white blood cell called a regulatory T cell suppresses these self-reactive immune cells. We have identified factors that govern the generation of regulatory T cells. Understanding how these factors work should permit the development of new strategies to combat autoimmune diseases. ?