Antibodies against erythrocyte invasion ligands of Plasmodium falciparum and protection from malaria

疟疾是全球儿童死亡的主要原因。疟疾寄生虫感染红细胞并在其中繁殖，如果不及时治疗，会导致严重的疾病。目前没有可用的疫苗，有效的治疗方法有限。在对非洲和巴布亚新几内亚儿童的研究中，我们的目标是确定阻断血液中疟疾感染和生长的免疫反应。有了这些知识，就可以设计针对疟疾的疫苗，以预防严重疾病和死亡。

Malaria is a leading cause of childhood death globally. Malaria parasites infect red blood cells and multiply inside them, resulting in severe illness if untreated. Currently there is no vaccine available and effective treatments are limited. In studies of children in Africa and PNG, we aim to identify immune responses that block infection and growth of malaria in the blood. With this knowledge, vaccines can be designed that target malaria to prevent serious illness and death.