Antioxidant glutathione peroxidase (GPx) mimetics and atherosclerosis: a role for targeted antioxidant therapy.

本研究探讨了抗氧化治疗的使用，旨在增加体内重要的抗氧化酶GPx1的功能，以减少非糖尿病和糖尿病患者的动脉粥样硬化。强有力的临床证据和我们最近发表的数据支持GPx1在限制动脉粥样硬化中的重要作用。我们现在将研究介导这些作用的分子机制，以及模拟GPx1功能的化合物是否能减少动脉粥样硬化。

This proposal investigates the use of antioxidant therapy, targeted at increasing the function of the body's important antioxidant enzyme GPx1, to reduce atherosclerosis both in a non-diabetic and diabetic setting. Strong clinical evidence and our recently published data support an important role for GPx1 in limiting atherosclerosis. We will now investigate the molecular mechanisms involved in mediating these effects and whether compounds that mimic GPx1 function reduce atherosclerosis.