A BubR1-centred network for non-invasively measuring human oocyte quality

卵母细胞质量是决定妊娠结局的最重要因素。因此，选择最好的卵母细胞进行体外受精等生育治疗将极大地提高成功率并降低成本。我们已经确定了主要的卵母细胞调节因子，并应用新的数字技术来测量单个卵母细胞中的这些调节因子。该项目将利用这一专门知识开发新的方法来评估卵母细胞的潜力，从而告知其是否适合用于生育治疗。

Oocyte quality is the most important determinant of pregnancy outcome. Selecting the best oocytes for fertility treatments like IVF would therefore greatly improve success rates and reduce costs. We have identified master oocyte regulators and have applied novel digital technology to measure these regulators in a single oocyte. This project will apply this expertise to develop new approaches for evaluating an oocyte’s potential thereby informing its suitability for use in fertility treatment.