Towards a cure for the beta-hemoglobinopathies

血红蛋白是红细胞中的主要蛋白质，并且对于将氧气从肺运输到组织是必不可少的。血红蛋白生成障碍是世界范围内最常见的遗传性疾病。这些疾病可以显着改善与升高的形式所产生的血红蛋白的发展胎儿，胎儿血红蛋白。我们已经确定了胎儿基因表达的一个重要的关键因素。我们现在将确定是否操纵这个因素可以治愈血红蛋白疾病。

Hemoglobin is the major protein in red blood cells and is essential for the transport of oxygen from the lungs to the tissues. The disorders of hemoglobin production are the commonest genetic diseases world-wide. These diseases can be markedly improved with elevation of the form of hemoglobin produced by the developing fetus, fetal hemoglobin. We have identified a key factor important for fetal gene expression. We will now determine whether manipulation of this factor can cure hemoglobin disorders.