To determine the dependance of blood cancers on high levels of Myc protein.

MYC是一种基本的细胞蛋白，但也是多种组织中癌症的常见驱动因素。在血癌中，Myc经常过度表达。相比之下，Myc在早期实体癌中很少过度表达，尽管在晚期通常水平升高。我们将采用独特的癌症模型，在这种模型中，Myc可以在血细胞发育的不同时间在不同的设定水平被激活，以解决不同水平的Myc在血癌演变中的具体贡献。

Myc is an essential cellular protein but is also a common drive of cancer in multiple tissues. In blood cancers Myc is frequently overexpressed. In contrast, Myc is rarely overexpressed in early stage solid cancers, although often elevated levels at later stages. We will employ unique models of cancer in which Myc can be activated at different set levels at different times during blood cell development to address what the specific contributions of different levels of Myc are in the evolution of blood cancers.