To determine whether Myc-driven transformation in haematopoietic cell lineages is dependent on high-levels of Myc protein expression.

确定造血细胞谱系中 Myc 驱动的转化是否依赖于高水平的 Myc 蛋白表达。

• 批准号: nhmrc : 1072477
• 负责人: Dr Megan Bywater
• 金额: $ 24.8万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determine-myc-driven-protein-expression/455515
• 关键词: determine; whether; Myc; driven; transformation

Myc is an essential cellular protein but is also a common drive of cancer in multiple tissues. In blood cancers Myc is frequently overexpressed. In contrast, Myc is rarely overexpressed in early stage solid cancers, although often elevated levels at later stages. We will employ unique models of cancer in which Myc can be activated at different set levels at different times during blood cell development to address what the specific contributions of different levels of Myc are in the evolution of blood cancers.

Myc是一种必需的细胞蛋白，但也是多种组织中癌症的常见驱动因素。在血癌中，Myc经常过度表达。相比之下，Myc在早期实体癌中很少过度表达，尽管在晚期经常升高。我们将采用独特的癌症模型，其中Myc可以在血细胞发育的不同时间以不同的设定水平被激活，以解决不同水平的Myc在血癌进化中的具体贡献。