The prefronto-striatal circuit and disorders of action control

执行障碍综合征是一种有害的计划和行动控制障碍，由影响大脑功能的各种条件引起。先前的研究集中在矫正额叶功能，但最近的研究表明，关键的缺陷在于连接前额叶皮层和背侧纹状体的皮质-皮质下回路。本项目从细胞和系统水平研究该回路的结构和功能，为治疗提供新的靶点。

Dysexecutive syndrome is a pernicious disorder of planning and action control induced by a variety of conditions affecting brain function. Prior research has focused on correcting frontal lobe function however recent research suggests that the critical deficit lies in a cortical-subcortical circuit linking prefrontal cortex with the dorsal striatum. This project with investigate the structure and function of this circuit at a cellular and systems level to provide new targets for treatment.