The predictors of type 2 diabetes in the Melbourne Collaborative Cohort study

1990年，我们建立了一项关于饮食与健康的长期研究。其目的是测量健康人的饮食和其他风险因素，以了解它们可能如何影响2型糖尿病(也称为成人发病或非胰岛素依赖型糖尿病)的未来发展。为此，我们招募了41,500名年龄在40岁至69岁之间的墨尔本人，测量了他们的饮食，并收集了有关生活方式、病史和常见疾病家族史的其他方面的信息。所有人都测量了身高、体重和血压，并提供了血样。人们的选择是为了包括男性和女性，以及来自意大利和希腊的移民。通过这种方式，我们可以扩大饮食习惯和其他生活方式指标的范围。从那时起，参与者完成了另一份问卷，并从自我报告和检查医疗记录中注意到疾病的发生。我们想要分析这项研究中700名患有2型糖尿病的人的数据。首先，我们将分析所有41,500人(在加入研究和后续行动时)收集的数据。接下来，我们将使用700名糖尿病患者和1400名年龄和性别相似的未患糖尿病的人的数据。这项研究的重点是测量血液中的物质。我们想要测量一系列脂肪、维生素、抗氧化剂、血管健康的标志，以及性激素和相关物质。然后，我们将能够估计这些因素对患糖尿病风险的影响。我们还将能够看到他们中是否有任何人共同行动，使某些男性和女性患糖尿病的风险更高。这项工作应该确定哪些生活方式的改变，特别是饮食，可以降低患糖尿病的风险，并帮助我们理解为什么会这样。这一点很重要，因为每年都有越来越多的人患上糖尿病。

In 1990 we set up a long-term study of diet and health. The aim was to measure diet and other risk factors in healthy people in order to see how they might affect future development of type 2 diabetes (also known as adult onset or non-insulin-dependent diabetes). To do this we recruited 41,500 Melbournians aged 40 to 69 years, measured what they ate and drank, and collected information on other aspects of lifestyle, medical history, and family history of common diseases. All had height and weight and blood pressure measured and gave a blood sample. People were selected so that men and women, and migrants from Italy and Greece would be included. In this way we could widen the range of dietary habits and other lifestyle indicators. Since then participants have completed another questionnaire and occurrences of disease have been noted from self-reports and from examining medical records. We want to analyse data from the 700 people in the study who have developed type 2 diabetes. First we will analyse data collected on all 41,500 (on joining the study, and at follow up). Next we will use data from the 700 people with diabetes and 1400 of similar age and sex who have not developed diabetes. This study will focus on measuring substances in the blood. We want to measure a range of fats, vitamins, antioxidants, a marker of the health of blood vessels, as well as sex hormones and related substances. We will then be able to estimate what affect these factors have on the risk of getting diabetes. We will also be able to see if any of them act together to make the risk of diabetes much higher in certain men and women. This work should identify what changes in lifestyle, especially diet, could reduce the risk of diabetes, and help us understand why this is so. This is important because every year more and more people are developing diabetes.