Assessment of alpha-galactosylceramide as a novel adjuvant for pandemic influenza: A virua vaccine

人类感染致病性禽流感H5N1甲型流感病毒的事件是首次证明这些病毒能够从鸟类直接传播给人类的文件。这些感染的致命性，以及人群中对这些病毒没有预先存在的免疫力的事实，引起了人们对这些病毒可能出现导致下一次流感大流行的担忧。接种疫苗是我们预防流感感染的最有效方法，但目前还没有市售的禽流感疫苗。此外，最近的证据表明，目前的疫苗策略可能不太有效。该提案旨在评估一种新的疫苗策略的有效性，该策略可促进针对潜在大流行性流感毒株的免疫保护。

The occurrence of human infections with pathogenic avian H5N1 Influenza A viruses was the first documentation of these viruses demonstrating an ability to directly transmit from birds to humans. The virulent nature of these infections, and the fact that there is no pre-existing immunity to these viruses in the human population has raised the concern that these viruses may emerge to cause the next influenza pandemic. Vaccination is our most effective way of protecting against influenza infection, however there are no commercially available avian influenza vaccines available. Moreover, recent evidence suggests current vaccines strategies may be less than effective. This proposal aims to evaluate the efficacy of a novel vaccine strategy that promotes immune protection against a potential pandemic influenza strain.