The mechanisms of infection of bronchial epithelial cells by human and avian influenza viruses in chronic airways disease

慢性气道疾病中人和禽流感病毒感染支气管上皮细胞的机制

• 批准号: nhmrc : 510762
• 负责人: Dr Ian Barr
• 金额: $ 26.38万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-infection-bronchial-airways-disease/96146
• 关键词: mechanisms; infection; bronchial; epithelial; cells

Influenza is an important infection that causes disease every year in the Australian population. People with lung disease are at particular risk to its effects. The ability of the virus to grow in birds and change its appearance to our immune system allows this virus to cause severe disease every year. We will examine the immune response to this virus in human cells, comparing this response to human and bird strains of the virus and see why subjects with lung disease are more susceptible.

流感是每年在澳大利亚人口中引起疾病的一种重要感染。患有肺部疾病的人尤其容易受到其影响。这种病毒能够在鸟类体内生长并改变其外观，从而影响我们的免疫系统，这使得这种病毒每年都能引起严重的疾病。我们将检查人类细胞对这种病毒的免疫反应，将这种反应与人类和鸟类的病毒株进行比较，并了解为什么肺部疾病的受试者更容易受到影响。