Atherosclerosis:Lipoproteins, cell biology and vascular physiology

该团队由国际公认的心血管疾病基础，临床和公共卫生应用研究专家组成，特别是动脉粥样硬化，这是澳大利亚和其他发达国家最常见的死亡原因。在过去的十年中，心血管健康的改善主要是由于更好地了解如何控制“坏”（或LDL）胆固醇。这些研究的意义在于，一方面，它们将提供关于“好”脂蛋白如何保护我们免受动脉粥样硬化的新信息。然后，这些信息可以用于以有意义的方式调节“好”胆固醇。另一方面，拟议的研究将提供一系列生活方式因素，生理过程和病理条件如何与血管衬里细胞的功能和个体对动脉粥样硬化的易感性相关的基本见解。

The team comprises internationally recognised experts in basic, clinical and public health applied research in cardiovascular disease, particularly atherosclerosis that is the commonest cause of death in Australia and other developed countries. Over the last decade, improvement in cardiovascular health has been primarily the result of a better understanding on how to control 'bad' (or LDL) cholesterol. The significance of the proposed studies is that, on the one hand, they will provide new information on how 'good' lipoproteins protect us from atherosclerosis. This information can then be used to regulate 'good' cholesterol in a meaningful manner. On the other hand, the proposed studies will provide fundamental insights into how a range of lifestyle factors, physiological processes and pathological conditions relate to both the function of blood vessel-lining cells and susceptibility of individuals to atherosclerosis.