Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement

这个项目将通过研究nabarlek或小岩袋鼠来研究哺乳动物的磨牙是如何形成的，nabarlek是少数几种能够在一生中再生新磨牙的哺乳动物之一。这些新牙齿通过骨骼移动，以便移动到口腔中的正确位置。通过研究两种研究得很好的生物，小鼠和袋鼠，以及纳巴莱克本身，我们将揭示与磨牙生成和移动有关的发育过程和基因。该项目将整合再生医学、进化生物学、材料工程学和古生物学的研究成果，以揭示这种惊人能力的机制和起源。

This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, as well as the nabarlek itself, the developmental processes and genes involved in molar generation and movement will be revealed. This project will integrate findings in regenerative medicine, evolutionary biology, materials engineering and palaeontology to reveal the mechanisms and origins of this astounding capability.