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Detection and inactivation of porcine parvovirus in pharmaceutical ingredients

Detection and inactivation of porcine parvovirus in pharmaceutical ingredients
药物成分中猪细小病毒的检测和灭活
批准号：
335018-2005
负责人：
Tijssen, Peter
金额：
$5.28万
依托单位：
Institut national de la recherche scientifique
依托单位国家：
加拿大
项目类别：
Collaborative Research and Development Grants
财政年份：
2006
资助国家：
加拿大
项目状态：
已结题
起止时间：
2006-01-01 至 2007-12-31
来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=325319
关键词：
Detectioninactivationporcineparvoviruspharmaceutical

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中文摘要
翻译
到目前为止，许多药物产品都是从生物来源生产的。当产品来源于动物源时，必须通过证明不存在病毒污染物来确保产品的安全性。本研究旨在开发一种检测猪细小病毒（PPV）的方法。尽管从未显示该病毒感染人类，但谨慎的做法是确保猪组织制剂中使用的纯化材料中不存在该病毒。本研究进一步旨在去除或灭活这些药物制剂中发现的残留病毒颗粒。
英文摘要
To this date, many pharmaceutical products are manufactured from biological sources. When the products are derived from animal sources, it is essential to ensure the safety of the product by demonstrating the absence of viral contaminants. This study aims at developing methods to assay for a common pathogen of pigs known as porcine parvovirus (PPV). Although this virus has never been shown to infect humans, it is prudent to ensure its absence from purified materials used in drug products derived from porcine tissues. This study further aims at removing or inactivating residual virus particles found in those pharmaceutical preparations.
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会议论文
Parvovirus structure-function relationships (viral cycle and tropism)
Parvovirus structure-function relationships (viral cycle and tropism)
Parvovirus structure-function relationships (viral cycle and tropism)
Parvovirus structure-function relationships (viral cycle and tropism)
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