Microscope repair and ethanol chambers

多年来，已经使用了几种输送酒精的系统，包括将药物作为液体饮食，通过胃、腹腔或静脉注射途径注射，以及将啮齿动物暴露于酒精蒸气中。每种方法都有优点和缺点，在文献中进行了大量讨论。然而，一直困扰研究的一个重要问题是难以达到可预测的血液酒精水平（BALs），如果需要的话，将其维持在给定的值内。我们建议使用拉霍亚酒精研究公司的吸入系统来克服这些关键障碍。该系统对环境安全，结构紧凑，易于使用，最重要的是，该系统可以在各种动物模型中实现并保持精确的靶向bal。此外，我们还要求为我们实验室显微镜的几个关键更换部件提供资金。

Over the years, several systems for the delivery of alcohol have been utilized, including presenting the drug as a liquid diet, injecting it via gastric, intraperitoneal or intravenous  routes, and by exposing rodents to alcohol vapors. Each method has advantages and drawbacks that are abundantly discussed in the literature.  However, one significant problem that has consistently plagued research is the difficulty in reaching predictable blood alcohol levels (BALs) and, if desired, maintain them within given values. We propose to use the La Jolla Alcohol Research, Inc. inhalation system to overcome these critical barriers. This system is environmentally safe, compact, easy to use and, most importantly, a system that could achieve and maintain precise targeted BALs in various animal models.   In addition, we are also requesting funds for several critical replacement components for microscopes in our laboratory.