Biochemistry molecular biology facility

这里要求的基础设施包括一个冷藏摇床培养箱和三台现有设备（磷化成像仪、化学成像仪和台式离心机）的服务合同。后者的基础设施是通过加拿大创新基金会提供的资金购买的，目前安置在北方生物科学研究单位（NBRU）的开放空间实验室中，该单位由7个小组组成，大约有40名成员。北卡罗来纳大学生物化学和分子生物学研究的这一重要骨干基础设施的保修期已经到期。该设备的服务合同将确保未来5年的继续和完整使用。所要求的冷藏摇床培养箱将大大缓解现有小型摇床培养箱的超额订购需求，并提高我们的生产力。此外，它将允许我们在15摄氏度或以下进行特定的实验，这在以前是不可能的。所要求的基础设施将支持并防止至少20个独立的研究项目的任何重大中断，这些项目由7名教师进行，其中2名是UNBC的研究主席。这些不同的研究项目包括了解mRNA衰减的酶学，mRNA前剪接机制，激酶的变质控制，分子昆虫学，血流调节，平滑肌细胞中的钙信号传导，以及极端湖泊中水生生物遗传多样性的研究。这些研究项目不仅对加拿大农村地区大量高素质人才的培训至关重要，而且还将成为不列颠哥伦比亚省北部知识型产业的催化剂，使其经济多样化。

The infrastructure requested here includes a refrigerated shaker incubator and service contracts for three pieces of existing equipment (PhosphorImager, ChemiImager and a benchtop centrifuge).  The latter infrastructure purchased through funds provided by the Canadian Foundation of Innovation is currently housed in the open space laboratories of Northern Biosciences Research Unit (NBRU) which comprises seven groups of about 40 members.  The warranties for this essential back-bone infrastructure for biochemistry and molecular biology research at UNBC have expired.  The service contracts for this equipment will ensure continuation and complete use for the next 5 years.  The requested refrigerated shaker incubator will significantly ease the over subscribed demand for the existing small shaker incubator and increase our productivity. In addition, it will allow us to perform specific experiments at or below 15 degrees celcius which was not previously possible.   The requested infrastructure will support and prevent any major interruptions of at least twenty separate research programs conducted by seven faculty members , two of which are Research Chairs, at UNBC.  These diverse research programs encompass understanding the enzymology of mRNA decay, pre-mRNA splicing mechanisms, allosteric control of kinases, molecular entomology, regulation of blood flow, calcium signalling in smooth muscle cells to the study of genetic diversity of aquatic organisms in extreme lakes.  These research programs are vital not only for the training of a large number of highly qualified personnel in a rural part of Canada, but will also serve as a catalyst for the initiation of knowledge-based industry to diversify the economy in northern British Columbia.