Bioenergetic deficit in neurodegeneration: studies in motor neuron disease (MND)

运动神经元病是一种致死性神经退行性疾病。没有已知的原因，也没有已知的治疗方法。我们认为，肌肉和神经细胞产生能量以维持生存的方式存在缺陷，会导致其已经很高的能量负荷增加代谢压力，最终导致细胞死亡。该项目旨在了解能量缺乏的恶性循环，导致导致肌肉和神经细胞死亡的灾难性事件。

Motor neurone disease (MND) is a fatal neurodegenerative disease. There is no known cause and no known cure. We believe that a defect in the way in which the muscle and nerve cells generate energy to sustain survival causes for there to be added metabolic stress on their already high energetic load, ultimately leading to cell death. This project aims to understand the vicious cycle of energy deficiency that leads to the catastrophic events that cause the death of muscle and nerve cells.