Bioresponsive Porous Silicon for Site Specific Oral Delivery of Antibodies for the Treatment of Inflammatory Bowel Disease

该提案旨在开发一种口服抗体递送系统，用于治疗影响75000名澳大利亚人的炎症性肠病（IBD）。该系统将基于多孔硅纳米颗粒作为保护抗体的容器，以及生物反应涂层作为通道，使特定部位的蛋白质能够在胃肠道炎症部位传递。该项目不仅为治疗IBD的蛋白质输送带来了希望，也为治疗糖尿病等其他疾病带来了希望。

This proposal aims to develop an oral antibody delivery system for treatment of inflammatory bowel disease (IBD) that affects 75000 Australians. The system will be based on porous silicon nanoparticles acting as a container to protect the antibodies, and bioresponsive coatings acting as gates to enable site specific protein delivery at the inflamed site of GI tract. The project not only holds promise for protein delivery for the treatment of IBD but other diseases like diabetes.