Building better ex vivo 3D cancer models with 3D printing

三维的细胞球，称为球状体，是体内肿瘤的更好模型，而不是在平面上的细胞，但在高通量生产方面具有挑战性。在这个项目中，我们将使用定制设计的3D打印机和新型生物墨水，模仿球体周围发现的蛋白质，以更好地制作体内癌症的体外模型。这些生物墨水将被调整以模拟不同的组织，并显示治疗药物的递送如何受到球体结构的影响。

Three dimensional balls of cells, called spheroids, are better models of tumours in vivo than cells plated on flat surfaces but are challenging to produce in high throughput. In this project we will use a custom designed 3D printer and novel bioinks that mimics of the proteins found around spheroids to make better in vitro models of in vivo cancers. These bioinks will be tuned to mimic different tissues and show how the delivery of therapeutics are affected by the spheroid architectures.