Optical Metasurface for Single Small Extracellular Vesicle Analysis

该项目旨在开发一种创新的纳米生物技术来研究细胞外小泡(SEV)--在细胞间通讯中非常重要的小生物颗粒。该技术将实现前所未有的分析深度和单粒子分辨率。它将通过提高SEV图像分辨率和根据不同SEV亚群的蛋白质表型收集关于不同SEV亚群分布的信息，在工程和生物科学方面产生新的知识。预期成果包括一个通用和超灵敏的平台，在分析生物化学方面有许多应用，如疾病诊断、环境科学、食品安全和农业。

This project aims to develop an innovative nanobiotechnology to study small extracellular vesicles (sEVs) – small biological particles that are important in intercellular communication. The technology will enable unprecedented depth of analysis and single particle resolution. It will generate new knowledge in both engineering and biological sciences by improving sEV image resolution and collecting information regarding the distribution of different sEV subpopulations based on their protein phenotypes. Expected outcomes include a universal and ultrasensitive platform with many applications in analytical biochemistry such as disease diagnostics, environmental sciences, food safety and agriculture.