Cell Death Pathways and Type 1 Diabetes

产生胰岛素的β细胞的丧失导致1型糖尿病和同种异体胰岛移植的排斥反应。该计划的目的是发现保护β细胞免受损伤的方法。我们将通过研究阻断细胞死亡的关键调节因子是否可以在体外和体内保护小鼠和人类β细胞免受破坏来做到这一点。在这样做的过程中，我们的目标是预防小鼠糖尿病，并有可能提高移植后胰岛移植物的存活率。

Loss of insulin-producing beta cells leads to type 1 diabetes and rejection of allogeneic islet transplants. The aim of this program is to discover ways of protecting beta cells from damage. We will do this by investigating whether blocking crucial regulators of cell death can protect mouse and human beta cells from destruction in vitro and in vivo. In doing so, we aim to prevent diabetes in mice and potentially improve the survival of islet grafts after transplantation.