Central glutamatergic pathways regulating the circadian rhythms of the autonomic nervous system and the autonomic response to sleep apnea.

自主神经调节的中枢通路是众所周知的，但特定通路在生理环境中的功能仍然是一个难以实现的目标。我们将评估两条生理上重要的自主神经通路在睡眠呼吸暂停和昼夜节律控制中的作用，方法是在转基因小鼠中通过基因删除递质谷氨酸。更好地了解这些通路对于揭示健康和疾病中自主神经系统的功能至关重要。

The central pathways of autonomic regulation are well known, but the functions of specific pathways in physiological settings remains an elusive goal. We will evaluate the role of two physiologically important autonomic pathways for sleep apnea and the circadian control of the body by genetically deleting the transmitter, glutamate, in transgenic mice. A greater understanding of these pathways is critical in unraveling autonomic nervous system function in health and disease.