Viral IRES-mediated translation under stress conditions

压力被定义为任何不利的刺激，身体上的，精神上的或情绪上的，内部的或外部的，往往会扰乱生物体的体内平衡并引起补偿性的生物反应。在现代社会，我们生活在各种各样的压力下，但我们以某种方式适应并继续我们的生活。同样地，我们体内的细胞也会对某些压力做出反应，改变基本功能的模式。蛋白质的合成对于细胞结构和功能的完整是不可或缺的。有一种独特的蛋白质合成方式，在营养缺乏、细胞损伤和细胞死亡的情况下变得活跃。我们认为这种翻译系统在维持细胞在压力下的稳态中起着重要的作用。我们的目标是回答细胞在应激条件下如何调节独特的蛋白质合成。建议的研究可以很容易地为一两个研究生提供论文项目。学员将接触到广泛的研究经验，如分子生物学、细胞生物学和蛋白质生物化学。在拟议的研究计划中培养的高素质人才将在未来对加拿大科学界，如学术界和卫生研究机构、生物技术公司和政府机构具有重要意义。

Stress is defined as any adverse stimulus, physical, mental or emotional, internal or external, that tends to disturb the organisms homeostasis and elicit compensating biological reactions. In our modern society, we live under various stress but we somehow adapt and go on with our lives. Likewise, cells within our bodies can change the modes of essential function in reaction to certain stress. Protein synthesis is indispensable for the integrity of cellular structure and function. There is a unique way of protein synthesis which becomes active under nutrient starvation, cell injury and cell death. We believe that this translation system plays important roles to maintain cellular homeostasis under stress. Our goal in this proposal is to answer how cells regulate the unique protein synthesis under stress conditions. The proposed study can readily provide thesis projects for one or two graduate students. The trainees will have exposure to a broad range of research experiences, such as molecular biology cellular biology and protein biochemistry. The highly Qualified Personnel trained in the proposed research program will be of great significance to the Canadian scientific community in the future, such as academics and health research institutions, biotechnology companies and government agencies.