Characterisation of the molecular mechanisms of Abeta-induced proteolysis of the neural cell adhesion molecule 2 (NCAM2)

大脑中的神经元通过突触接触联系在一起。阿尔茨海默病患者大脑中积累的淀粉样β蛋白通过降解维持突触结构的突触细胞黏附分子来破坏突触接触。该项目的目的是描述淀粉样β蛋白依赖的突触细胞黏附分子降解的分子机制。该项目将确定可用于抑制阿尔茨海默病突触丢失的策略。

Neurons in the brain are connected by synaptic contacts. Amyloid beta peptide accumulating in the brain in Alzheimer’s disease destroys synaptic contacts by degrading synaptic cell adhesion molecules which maintain the structure of the contacts. The aim of the project is to characterise the molecular mechanisms of amyloid beta-dependent degradation of synaptic cell adhesion molecules. The project will identify strategies that can be used to inhibit synapse loss in Alzheimer’s disease.