Ultrasonic spectroscopy system for biomedical material and tissue characterization

超声波光谱系统将与超声波脉冲发生器/接收器和机械平移阶段购买的研究资助。该系统将由申请人设计和建造。它支持申请人的发现补助金（DG）研究计划（2007-2011），题为“压电和超声传感器和非侵入性生物医学监测和诊断技术”。在DG计划中，开发了超声探头，算法，数字信号处理技术和计算机软件，用于从生物组织的测量弹性特性构建超声图像。生物医学材料和组织的粘弹性通常取决于超声频率和温度。因此，使用超声纵波和横波测量它们的复弹性常数，同时测量温度，对于精确评估它们的粘弹性性质是期望的。利用该资助建造的超声光谱系统将用于通过使用申请人开发的探头和技术测量生物医学材料和组织的超声传播特性（作为超声频率和温度的函数）来创建生物医学材料和组织的粘弹特性数据库。这样的数据库可以提供有用的信息，这些信息可以用于组织的弹性成像、患病组织的临床诊断、组织表征和新的生物医学材料的开发。此外，作为温度的函数的组织特性将提供一种工具来研究热疗中的治愈程度，热疗是用于癌症治疗的有前途的技术之一。

An ultrasonic spectroscopy system will be constructed with an ultrasonic pulser/receiver and mechanical translation stages purchased by this research grant. The system will be designed and constructed by the applicant. It supports applicant's Discovery Grant (DG) research program (2007-2011), entitled "Piezoelectric and ultrasonic sensors and techniques for non-invasive biomedical monitoring and diagnosis". In the DG program, ultrasonic probes, algorithms, digital signal processing techniques, and computer software for the construction of ultrasonic images from the measured elastic properties of biological tissues are developed. Viscoelastic properties of biomedical materials and tissues generally depend on ultrasonic frequency and temperature. Thus, measurement of their complex elastic constants using ultrasonic longitudinal and shear waves with simultaneous measurement of temperature is desired for accurate evaluation of their viscoelasitc properties. The ultrasonic spectroscopy system constructed with this grant will be used to create a database of viscoelastic properties of biomedical materials and tissues by measuring their ultrasonic propagation characteristics as functions of ultrasonic frequency and temperature with probes and techniques developed by the applicant. Such a database could provide useful information which can be used for elastic imaging of tissues, clinical diagnosis of diseased tissues, tissue characterization and development of new biomedical materials. Furthermore, tissue properties as a function of temperature will provide a tool to investigate a degree of cure in hyperthermia which is one of promising techniques for cancer treatments.