Discovering and developing new chemistry for phosphorus, arsenic, antimony and bismuth

新材料、催化剂和药物的发现和发展依赖于对分子结合方式(结构和化学键)以及它们与其他化合物的反应方式(化学反应)的基本了解。由于碳元素在生命功能中的直接重要性，碳的化学有一个巨大的数据库可用。然而，与之相比，其他元素的化学只是表面上的发展。由于显性元素(磷、砷、锑和铋)在发现有效的无机药物、新型聚合物材料和新的电子材料方面的重要性，需要彻底和全面地了解它们的基本化学。我们正在研究高效有效的制备或合成路线，以获得含有P、As、Sb或Bi的新的、基本重要的分子，其中pnitogen中心显示出不寻常的局部结构，参与新的连接性，或提供具有新的、光谱、物理或反应性的材料。我们正在建立基础化学的新方向，我们的研究计划正在改变化学家们一般看待非金属元素化学的方式。致癌物质是特别有趣的元素，因为它们通常容纳一对孤立的电子，但同时也可以携带正电荷。因此，在这种情况下，我们正在发展作为Lewis受体的富电子致癌中心的配位化学。我们2006-2010年的研究计划的目标是合成和表征以下化合物：1)发展阳离子Lewis受体的配位化学。2)作为磷化学新方向的第一个链状多磷阳离子的合成与表征。3)制备由富电子的PNictogen Lewis受体络合物衍生的扩展体系。

Discovery and development of new materials, catalysts and pharmaceuticals relies on the fundamental understanding of the way in which molecules are held together (structure and chemical bonding) and the way they react with other compounds (chemical reactivity).  An enormous database is available for the chemistry of carbon due to the direct importance of this element in life functions.  However, the chemistry of other elements is superficially developed in comparison.  The emerging importance of the pnictogen elements (phosphorus, arsenic, antimony and bismuth) in the discovery of effective inorganic pharmaceuticals, novel polymeric materials and new electronic materials, requires a thorough and comprehensive understanding of their fundamental chemistry.  We are investigating efficient and effective preparative or synthetic routes to new, fundamentally important molecules containing P, As, Sb or Bi, in which the pnictogen center exhibits an unusual local structure, is engaged in a new connectivity, or provides materials with new, spectroscopic, physical or reactivity properties. We are establishing new directions in the fundamental chemistry of the pnictogens and our research program is changing the way in which chemists consider the chemistry of the non-metal elements in general.  The pnictogens are especially interesting elements as they typically accommodate a lone pair of electrons, but can simultaneously carry a positive charge.  In this context, we are developing the coordination chemistry of electron-rich pnictogen centers as Lewis acceptors. The objectives of our research programs for 2006-2010 are the synthesis and characterization of compounds that represent: 1) Development of the coordination chemistry of pnictogen cation Lewis acceptors. 2) The synthesis and characterization of the first catena-polyphosphorus cations as a fundamental new direction in phosphorus chemistry. 3)  The preparation of extended systems derived from complexes of electron-rich pnictogen Lewis acceptors.