Can Pentoxifylline improve long-term outcomes in preterm infants with late-onset sepsis or necrotizing enterocolitis – a pragmatic, randomized, controlled trial

极早产儿死亡和残疾的风险很高。脑损伤通常是感染或肠道疾病引起的炎症的结果。到目前为止，还没有治疗方法来减少炎症的有害影响。喷替福林可减少炎症，是一种有前途的，安全和廉价的治疗选择早产儿。本研究将确定除抗生素外，是否可提高早产儿无残疾生存率。

Very preterm infants are at high risk of death and disability. Brain injury is often the result of inflammation caused by infection or bowel disease. To date, there is no treatment to reduce the harmful effects of inflammation. Pentoxifylline reduces inflammation and is a promising, safe and inexpensive treatment option for preterm infants. This study will determine whether Pentoxifylline in addition to antibiotics improves survival without disability in preterm infants.