Insulin signaling and action in skeletal muscle: regulation by crosstalk with leptin and resistin signaling

胰岛素是已知的最著名的荷尔蒙之一，在令人惊讶的大范围物种中具有广泛的重要性。这是因为胰岛素用于控制细胞功能的机制在整个进化过程中一直非常保守。我的研究项目进行的工作重点是胰岛素控制细胞功能的这种能力是如何受到其他激素的调节的，在这种情况下是瘦素和抵抗素。能够在细胞水平上识别这些事件将在为未来的应用研究提供基本的生物学框架方面发挥重要作用，因此对哺乳动物生理学具有广泛的相关性。

Insulin is one of the most famous hormones known and has a widespread importance across a surprisingly large range of species. This is due to the fact that the mechanisms which insulin uses to control the function of cells has been very highly conserved throughout evolution. The work conducted by my research program focuses on how this ability of insulin to control cell function is regulated by other hormones, in this case leptin and resistin. Being able to identify these events at the cellular level will play an important role in providing the basic biological framework for future applied studies and is thus of widespread relevance to mammalian physiology.