Accessories for the centre for biological applications of mass spectrometry

康考迪亚大学成立了质谱生物应用中心（CBAMS），以支持和促进研究，并为学生提供应用质谱技术解决生物化学中各种问题的实践培训。CBAMS目前拥有7台质谱仪，这些质谱仪主要是由1994年以来授予康考迪亚研究人员的赠款资助的。在目前的申请中，需要四个质谱仪的附件，以增加可以进行的实验范围，并提高中心的效率。该仪器由CIHR资助，用于生物基质中的金属离子分析，并于2006年安装在CBAMS中，需要一套微波压力消解系统，以安全、可重复地制备ICP-MS样品。需要一个纳米lockspray附件，以便在2002年用NSERC基金购买的Q-TOF质谱仪上进行精确的质量测量。一种新的激光器被要求用于MALDI-ToF，它也在2002年用NSERC基金购买。目前使用了三年的激光器对于分析许多类型的样品来说太弱了。2007年1月在CBAMS安装的三重四极质谱计需要一个专用的注射泵和水冷器。该仪器（Waters Quattro LC）由圣地亚哥辉瑞公司捐赠给CBAMS。所要求的项目不仅将增加咨委会的能力，还将有助于增加使用者的数量，并加强咨委会在大学研究中的作用。随着可用的质谱仪范围，CBAMS是加拿大最全面的学术质谱中心。它在致力于学生和研究人员的实践培训方面也是独一无二的。

The Centre for Biological Applications of Mass Spectrometry (CBAMS) was established at Concordia University to support and promote research, and to provide students with hands-on training in the applications of mass spectrometry to diverse problems in biological chemistry. CBAMS currently houses seven mass spectrometers that were funded largely by grants awarded to Concordia researchers since 1994. Accessories for four of the mass spectrometers are requested in the current application to increase the range of experiments that can be performed as well as to improve the efficiency of the Centre.A microwave pressure digestion system is requested to safely and reproducibly prepare samples for ICP-MS on an instrument that was funded by CIHR for metal-ion analysis in biological matrices, and installed in CBAMS in 2006. A nanoLockspray accessory is requested to allow accurate mass measurements on the Q-TOF mass spectrometer purchased with NSERC funds in 2002. A new laser is requested for the MALDI-ToF, which was also purchased with NSERC funds in 2002. The current three-year-old laser is too weak for the analysis of many types of samples. A dedicated syringe pump and water cooler are requested for the triple quadrupole mass spectrometer that was installed in CBAMS in January 2007. This instrument (Waters Quattro LC) was donated to CBAMS by Pfizer in San Diego.  The requested items will not only bring additional capability to CBAMS, they will serve to increase the pool of users and to strengthen the role of CBAMS in research in the University. With the range of available mass spectrometers, CBAMS is the most comprehensive academic mass spectrometry centre in Canada. It is also unique in its dedication to the hands-on training of students and researchers.