Regulation of growth hormone profile by metabolic balance: neuronal, neuroendocrinal and molecular mechanism

肥胖与生长激素分泌减少有关。由于生长激素以牺牲脂肪为代价来维持肌肉质量，这可能会进一步加剧肥胖状况。该项目将确定Ghrelin在正常、禁食和肥胖条件下维持生长激素分泌的生理作用。Ghrelin是一种发出饥饿信号的激素。阐明Ghrelin在调节生长激素分泌中的作用可能有助于开发药物来帮助和维持减肥。

Obesity is associated with a reduction in growth hormone secretion. As growth hormone maintains muscle mass at the expense of fat this may further promote the obese condition. This project will determine the physiological role of ghrelin, a hormone that signals hunger, in maintaining growth hormone secretion under normal, fasting and obese conditions. Clarification of the role of ghrelin in regulating growth hormone secretion may aid in the development of pharmacological agents to assist and maintain weight loss.