Phosphorylation of Nck

人体由各种组织组成，这些组织又由具有特殊功能的细胞组成。人体细胞功能的协调调节涉及通过调节细胞蛋白活性的生化过程。其中一个影响蛋白质活性的重要修饰涉及到这些特定蛋白质被定义为蛋白激酶的特殊酶磷酸化。我们的实验室对蛋白质磷酸化的基础研究和参与这一过程的蛋白激酶的鉴定感兴趣。作为一个工作模型，我们将重点放在小蛋白Nck上，我们发现Nck在各种已知的应激条件下被严重磷酸化，从而激活特定的蛋白激酶子集。我们的研究将通过提供对调节人类细胞功能的基本机制的详细了解，使整个科学界受益。

The human body is composed of various tissues, which in turn consist of cells that have specialized functions. The coordinated regulation of the human cell functions involves biochemical processes mediating the modification of the activity of cellular proteins. One such important modification that affects protein activity implicates the phosphorylation of these specific proteins by specialized enzymes that are defined as protein kinases. Our laboratory is interested in the basic study of protein phosphorylation and in the identification of the protein kinases participating in this process. As a working model, we focus on the small protein Nck that we have found heavily phosphorylated in various stress conditions known to activate a specific subset of protein kinases. Our research will benefit the whole scientific community by providing a detailed understanding of fundamental mechanisms regulating the human cell functions.