New Methodologies for the Organic Modification of Solid Surfaces

在固体表面上固定有机和生物有机分子是纳米技术和微阵列技术的中心目标。传感器和分子电子器件的发展与分子操作和表面吸附控制的固定技术和方法的进步直接相关。我的长期目标是开发分子电子器件，用于传感应用。我最初的重点是化学的三个重要方面，这是使这种技术成为可实现的技术所必需的；(1)发展用有机分子对固体表面进行有效修饰的新方法；(2)对表面进行严格的表征并研究薄膜的电化学性质；(3)在高度局部水平上对吸附物进行电化学操作。导电（Au和Ag）和半导体（Si）表面都将被研究。虽然制备SAM的大多数实验条件都能产生具有某些应用可接受的特定理想功能的可再生有机界面，但其他基本性能仍需要进一步研究和优化，包括腐蚀和电化学性能。这与开发缺陷更低、有序度更高的地对空导弹有着内在的联系。另一方面，无氧化物硅表面的有机修饰提供了分子材料和固态半导体结构的直接组合，并且是技术上有用和分子可调谐薄膜的有吸引力的方法。这个提议的想法是利用我在基于电子转移的反应，电合成和SAM电化学方面的经验来开发表面衍生化和局部操纵问题的化学解决方案。

The immobilization of organic and bioorganic molecules on solid surfaces is a central objective in nanotechnology and microarray technologies. Developments in sensors and molecular electronic devices are directly related to advances in immobilization techniques and methodologies for molecular manipulation and control of surface adsorbates. My long-term objective is the development of molecular electronic devices, for use in sensing applications. My initial thrust concerns three important aspects of the chemistry necessary to make this a realizable technology; (i) the development of new approaches for the efficient modification of solid surfaces with organic molecules, (ii) the rigorous characterization of surfaces and investigation of the electrochemical properties of the films, and (iii) the electrochemical manipulation of adsorbates on a highly local level.Both conducting (Au and Ag) as well as semiconducting (Si) surfaces will be investigated. While most experimental conditions for SAM preparation yield reproducible organic interfaces with specific desirable functionalities that are acceptable for some applications, other fundamental properties need still to be further studied and optimized including corrosion and electrochemical properties. This is intrinsically related to the development of SAMs with lower defects and increased order. On the other hand, the organic modification of oxide-free Si surfaces offering a direct combination of molecular materials and solid-state semiconductor structures and is then an attractive approach toward technologically useful and molecularly tunable thin films.The idea of this proposal is to use my experience in electron transfer based reactions, electrosynthesis and SAM electrochemistry to develop chemical solutions to the issues of surface derivatization and local manipulation.