Regulation of Mesenchymal to Epithelial Transitions by Netrin Receptors

2D细胞片的形成在发育、组织修复和肿瘤生长过程中非常重要。然而，其中涉及的机制在很大程度上仍不清楚。在果蝇和人类细胞中的最新发现表明，疲劳/新生素受体通过在细胞中建立极化支架来驱动这一过程。我们将使用苍蝇遗传学和哺乳动物细胞的三维培养分析来验证这一假设。我们的结果将有助于指导未来人类疾病的治疗。

The formation of 2D cellular sheets is important during development, tissue repair, and tumor growth. The mechanisms involved, however, remain largely unknown. Recent findings in the fly and in human cells suggest Frazzled/Neogenin receptors drive this process, by establishing polarised scaffolds in the cell. We will test this hypothesis using fly genetics and analysis of 3-dimensional culture of mammalian cells. Our results will help guide future therapies for human disease.