Regulation of the placental renin-angiotensin system by microRNAs; implications for pregnancies complicated by placental insufficiency?

宫内生长受限（IUGR）和先兆子痫（PrE）对母亲和婴儿都有生命威胁，使婴儿成年后易患疾病。PreE和IUGR的主要原因之一是胎盘形成。胎盘形成受胎盘肾素-血管紧张素系统（RAS）的影响，该系统由microRNA控制。我们将描述这些microRNA，是什么控制着它们;确定它们在正常妊娠，IUGR和PrE中的表达和RAS表达，从而为它们的早期检测提供新的生物标志物。

Intrauterine growth restriction (IUGR) and preeclampsia (PrE) are life threatening to mother and baby, making the baby susceptible to disease as an adult. One of the major causes of PreE and IUGR is placentation. Placentation is affected by the placental renin-angiotensin system (RAS), which is controlled by microRNAs. We will describe these microRNAs, what controls them; determine their expression and RAS expression in normal pregnancy, IUGR and PrE, thus providing novel biomarkers for their early detection.