Regulation of virulence gene expression in Clostridium perfringens

这个项目涉及对一种引起气性坏疽的细菌的分析。我们已经证明了一种以前未知的调节蛋白调节这种细菌致病的能力。我们的目标是确定是什么启动了蛋白质的活性，它如何控制导致疾病的因素，以及哪些特定因素参与了疾病。主要成果将是更好地了解毒力基因调控的机制，这将导致改进疾病控制方法。

This project involves the analysis of a bacterium that causes gas gangrene. We have shown that a previously unknown regulatory protein modulates the ability of this bacterium to cause disease. We aim to determine what turns on the protein's activity, how it controls the factors that contribute towards disease and what specific factors are involved in disease. The major outcome will be a better understanding of the mechanisms of virulence gene regulation, which will lead to improved methods of disease control.