Regulator of G-protein Signalling-5: a key modulator of vascular maturation and the

肿瘤逐渐生长，部分原因是它们逃脱了免疫系统的破坏。新的血管通过一种叫做血管生成的过程在肿瘤内生长，这反过来又阻止了抗病细胞的运行。然而，我们现在发现，通过使血管正常化来逆转血管生成是可能的。这实际上意味着屏障被打破，肿瘤可以向免疫系统或抗癌药物开放。此外，我们已经确定了一种蛋白质，它似乎对正常化非常重要，这一过程目前尚不清楚。这项建议延续了我们在血管正常化方面的开创性工作，并将使用具有最高临床相关性的模型来研究肿瘤中血管重构的动力学。我们的方法与目前的血管生成研究不同，目前的研究只是试图阻断或破坏滋生肿瘤的血管。我们希望我们的发现能带来高度特异和有效的抗肿瘤疗法。此外，肿瘤中的血管生长与体内的其他血管过程有着惊人的相似之处，这对高血压和动脉粥样硬化等重大和常见的人类疾病具有重要意义。在我们新建立的疾病模型中，我们现在有了研究这些过程及其异常的工具。通过对这些疾病的深入了解，我们将能够开发出阻止疾病进展的新方法。

Tumours progressively grow in part because they escape destruction by the immune system. New blood vessels grow inside tumours by a process called angiogenesis, which in turn stops disease-fighting cells in their tracks. However, we have now discovered that it is possible to reverse angiogenesis by normalising the blood vessels. This effectively means the barriers are broken down and the tumour can be opened to the immune system or cancer fighting drugs. Furthermore, we have identified a protein which appears to be very important for normalisation, a process which is currently not well understood. This proposal continues our pioneering work on vessel normalisation and will use models of highest clinical relevance to study the dynamics of vessel remodelling in tumours. Our approach is different to current angiogenesis research which simply tries to block or destroy the blood vessels that feed tumours. We expect our findings to lead to highly specific and effective anti-tumour therapies. Moreover, vessel growth in tumours has striking parallels to other vascular processes in the body, which have important implications for major and common human diseases such as high blood pressure and atherosclerosis. We now have the tools to study these processes and their abnormalities in our newly established disease model. By gaining insight into these disorders we will be able to develop novel approaches to stop disease progression.