Relaxin receptor structural determination to aid therapeutic development

多肽激素松弛素的受体RXFP1是许多制药公司治疗心血管疾病的靶点。然而，松弛素如何结合和激活RXFP1的分子细节的缺乏阻碍了新药的开发。我们将确定与RXFP1结合的松弛蛋白复合体的结构以及激活细胞的机制。所获得的知识将有助于针对RXFP1治疗心血管疾病的新药的设计。

The receptor for the peptide hormone relaxin, RXFP1, is being targeted by numerous drug companies for the treatment of cardiovascular disease. However, the lack of molecular detail of how relaxin binds and activates RXFP1 is hindering new drug development. We will determine the structure of the complex of relaxin bound to RXFP1 and the mechanism by which this activates cells. The knowledge gained will aid in the design of new drugs targeting RXFP1 for the treatment of cardiovascular disease.