Repair of the nigrostriatal pathway by phenotype shift of dopamine neurones

修复受损的大脑将取决于开发新的细胞，这些细胞可以形成正确的细胞类型，建立正确的连接，并整合到正常的大脑电路中。我们发现，在帕金森氏症中丢失的多巴胺细胞在成年啮齿动物的大脑中正在更新。这项研究旨在寻找控制这一过程的因素，并利用这些因素进行治疗。我们提供的证据表明，这种药物可用于治疗帕金森氏症。

Repairing the injured brain will depend on developing new cells that can form the correct cell type, make the right connections and be incorporated into normal brain circuitry. We have found that dopamine cells, which are lost in Parkinson's Disease, are being renewed in the adult rodent brain. This study is directed at finding factors that control this process and to exploit these factors therapeutically. We provide evidence that this can be used to treat Parkinson's Disease.