Repurposing Amiloride into Breast Cancer Drugs with a Dual-Targeting Mechanism

该项目旨在将一种利尿剂药物（阿米洛利）转化为一种通过一种新的分子机制起作用的乳腺癌药物。药物化学科学将用于去除阿米洛利的利尿作用，同时获得针对两种乳腺癌靶点的有效双重活性，uPA和NHE1。我们的研究将验证癌症治疗的新药理学方法，并生产适合开发为一流乳腺癌药物的专利药物。

This project aims to transform a diuretic drug (amiloride) into a breast cancer drug that acts via a novel molecular mechanism. The science of medicinal chemistry will be used to remove amiloride's diuretic effects whilst gaining potent dual-activity against two breast cancer targets, uPA and NHE1. Our study will validate a new pharmacological approach in cancer treatment and produce patented drugs suitable for development into first-in-class breast cancer drugs.