The Use of Nitric Oxide to Control Infections by Biofilm Forming Bacteria

使用一氧化氮控制生物膜形成细菌的感染

• 批准号: nhmrc : 568841
• 负责人: A/Pr Michael Kelso
• 金额: $ 36.79万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/use-nitric-oxide-forming-bacteria/96766
• 关键词: Use; Nitric; Oxide; Control; Infections

80% of infections are the result of bacteria growing as a biofilm. It can require up to 1000x's the normal antibiotic concentration to kill a biofilm. When the bacteria disperse from the biofilm, they become antibiotic sensitive again. Our team has identified a strategy that controls biofilm dispersal. This project will design and test novel compounds that disperse biofilms so that they can be killed by the host immune response or by antibiotic treatment.

80%的感染是细菌作为生物膜生长的结果。它可能需要高达1000倍的正常抗生素浓度才能杀死生物膜。当细菌从生物膜中扩散时，它们再次变得对抗生素敏感。我们的团队已经确定了一种控制生物膜扩散的策略。该项目将设计和测试分散生物膜的新型化合物，以便它们可以被宿主免疫反应或抗生素治疗杀死。