Role of the Anaphase-Promoting Complex activator Cdh1 in Oocyte Maturation and Meiotic Aneuploidy

含有不正确数目染色体的卵子被称为非整倍体。该项目旨在研究非整倍体的分子原因，以及为什么它会随着女性年龄的增长而增加。我们专注于Cdh 1蛋白在这一过程中的保护作用。结果将是更好地了解非整倍体的起源，以便找到随着女性年龄的增长而减少它的方法。这是非常重要的，因为非整倍体是早期胚胎丢失的主要原因，并产生唐氏综合症婴儿。

Eggs containing an incorrect number of chromosomes are described as aneuploid. This project sets out to examine the molecular causes of aneuploidy and why it increases with female age. We focus on the protective role of the protein Cdh1 in this process. The outcome would be to better understand the origins of aneuploidy so as to find methods of decreasing it as women age. This is highly significant given aneuploidy is the leading cause of early embryo loss and produces Down Syndrome babies.